I have the same issue. Have to reapply the filters every time I open the browser. It used to only lose the setting every couple of days but now it does it every time. I have the latest version - 3.55.2393.596
I’ve also noticed that about once a week, the browser forgets all the tabs I was working on (I have continue where I left off selected) and makes me start again with a blank home page. Fortunately I can go into history and restore the tabs one by one but it is still a pain that it no longer works as advertised.