ADNM and Active Directory Problem

I’m installing avast! managed client in a Windows network to use ADMN.
Apparently everything is fine. However, after the installation we encountered problems in some machines: Locks and failures with some applications like MS Office. In these managed clients, when the user is signed with an administrator account all problems disappears.

The network administrator are using Active Directory to limit and controlling access data to all users. Obviously here is the problem.

What file or folder should not be limited access to managed client?