Autosandbox and site blocking are fully integrated into the program, there are no separate modules for them (and if they were, they would have a few KB) - so no, it’s not possible.
As for the SafeZone… that could be separated, in my opinion - but I don’t know if there are any technical reasons for the current state.

By far the biggest part of the installation are the virus definitions and the setup packages - neither of which can be removed, because it would stop working. So I am sorry, but the “bare minimum” is basically what is inside the installation folder right now - a few hundreds of kilobytes more or less for some small features really don’t matter.