system
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Apparently Avast blocks the App Store connection unless you disable Scan secure connections. Of course there is no hint that is what you need to do.
I think there needs to be a better method of allowing exceptions.
edit: I’m not sure what is going on now. If scan secure connections is enabled on my Late 2012 iMac running 10.9.3 I get this error when I choose updates in the App Store app.
The operation couldn’t be completed. (NSURLErrorDomain error -1012.)
On my new MBA running 10.10 I have no problem.