Asyn
2
You can report a suspicious/malicious file here: https://www.avast.com/report-malicious-file.php
VirusTotal just tests against the signatures really. You need to actually execute the sample to see if it can go past CyberCapture, DeepScreen, Cloud and the Behaviour Shield.
mchain
4
Some, if not most, of the a/v engines available on VT are not the full featured versions available, just so you know.