It is a safety net, not all programs are going to have an intervention were you have to select an option. Why not as you find a program which you are sure is clean and trust, just select Open normally and check the Remember my answer for this program option, done.
After a short time if you have many occurrences of different program being pinged you will have dealt with them as above. Now you have that additional level of protection without too much hassle, it just takes a little time when you start.
Personally I feel you are doing others a disservice in having them disable it, educate them and let them make their minds up.