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Since I have/had the same problem, commented in another thread but noone ever picked up on it, I will comment here.
I can understand that this problem is not affecting 99% of Avast users but I found at least a dozen of threads with users complaning and only after I visited the Microsoft forum did I found a sticky there.
No sticky or acknowledgement of the problem in the avast forum which I visit regularly. Had I read sth. here, I would have not update to the most current version 6.
Microsoft doesn't support Vista RTM/SP1 anymore
This is simply not true. Support for Vista SP1 does end in a month on July 15.
That being said, I think the most important thing right now is to keep Vista users informed of the problem. Have a sticky here in the forum and tell people that Avast 6 is NOT compatible with Vista RTM and Vista SP1.
I myself uninstalled Avast after the validation error occured, everything worked perfectly then. Bottom line: I had to switch to another AV software.