Hello,
im running Windows 10, Avast Premier, Antibrowser Spy and Anti-Malwarevytes.
When running Avast Clean up starts it notice unneeded Data and recommends to Scan Registry next / after that step.
I tried hundred times…it finished wit the Message " It does´nt worc, a Problem occured…try again later"
But later try has got the same result.
Who of you can deliver the deciding Tip to me ? 
Thanks a lot !