Hard to know what to suggest - I have W7sp1, IE10 and avast free and have no issues.

You could try an avast repair - Control panel, uninstall, repair. I’ve rarely known it solve a problem though.

You could also try completely uninstalling the scriptshield component from avast to see if that solves it.

What other addons or plugins does your IE10 have - you could try disabling them.