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I’ll second what w0mbat says. I have also used MailWasher, both PRO and free, with avast! with no problems.
The mail scanning is completely independent of MailWasher. MW does not download the email, at least not any kind of attachments, executables, webbugs or whatever that might be harmful (only text). Whatever email I decide to keep after reviewing it is downloaded into Outlook and is scanned by the avast! Oulook program as normal.
If it is possible to download something harmful in MW the resident scanner should catch it, but I have never heard of anything like that happening and I believe it would be very unlikely if not impossible. I believe you will actually be safer using MW along with avast! as another layer of defense as you can delete all questionable email on the server.
Technical might be able to explain better or correct me, but I’m positive you will not be any less safe with mailwasher.
Jarron