I would get rid of Spybot & ad-aware then do a search for any left over crap, if you know how to check the regestry look in there for any spybot or ad-awere, or you could use Eusing a good free reg cleaner.

I would uninstall Avast & reinstall. What are you using in Comodo just the firewall?
Keep Malwarebytes for scanning. I use windows defender as a realtime protection but that’s me.
I do have Malewarebytes to scan.