Whilst this is strange to have a different reaction on two systems with the same OS.
Do you have the same security applications installed on both systems ?

Personally I think Spybot - Search and Destroy is a somewhat dated program - it is absolutely years since I gave up on it for the likes of MBAM (MalwareBytes AntiMalware), but it should work consistently across systems. Do you have Spybot’s - Tea Timer functions enabled as that has in the past effected avast.

I just wonder if this programs actions monitoring startup entries could be considered suspect. That said if you have the same settings for spybot on both systems, the result should be the same.