iYogisolutions1 you keep advising people to place exclusions in the settings\exclusions and as told to you many times before this will only exclude from an on demand scan and does not stop conflicts that will occure between avast and the said programs, exclusions would need to be added to the file system shield exclusion’s and probably adding the programs exe files to the behaviour shield would also be required but with that aside the OP was asking if avast can be installed on the D Drive which i believe is not possible as it needs to be installed on the same drive as the operating system which is usually C Drive.