I am getting the same error on Win7 Sp1 after updating from previous ver. [Avast 17.3.2291]
I did an automatic update from within Avast Free itself, after downloading and updating this gave the ‘Unknown error’ when trying to download ‘servers.def.vpx’.
I then downloaded the off-line version of the latest Avast Free [avast_free_antivirus_setup_offline.exe for ver [17.4.2294]].
I installed this and got the same result.
I have checked my firewall and NO IP addresses are being blocked when I manually perform the update of Virus Definitions etc.
See attachment for example of error.