If services or startup programs need disabling then it would be better to use the services function within windows although tinkering could cause problems and i find the majority of these “tuning” programs to be just vaporware junk with no real added bonus.
Problem is that if you tinker using 3rd party software and then the software either becomes corrupted or the user uninstalls it then the system is going to be unstable.
For startups i would use AUTORUNS from sysinternal software.
Also just because a program finds and cleans more does not mean it is cleaning safely.
IF IT AINT BROKE THEN DONT TRY TO FIX IT.
Thank You.