mchain
11
As essexboy says:
https://en.wikipedia.org/wiki/CryptoLocker
http://www.bleepingcomputer.com/virus-removal/cryptolocker-ransomware-information
Removing avenues of attack and exploitation is a sound strategy. So removing Adobe Flash plug-in or disabling it to run only as needed would be a part of that strategy. Especially since authors are known to specifically target commercial businesses or institutions as files lost are more valuable to them than average consumer.
What modifying the CryptoLocker dropper means is that no antivirus can detect and block until a definition is created for it, not just Avast.