Can Defragging The registry affect avast without one knowing with a program such as Glary Utilities! Not Cleaning Registry only defragging it!
It shouldn’t hurt anything. I use the XP version of PcTools Registry Mechanic to periodically “compact” the registry which is doing the same thing.
After cleaning my registry with Glary Utilities I noticed that Avast’s windows gadget stopped working, to get it to work again I had to re-run the Avast set up and repair it… The gadget was there but the buttons stopped working, removing it and re-adding didnt help… - I told you this just in case that you might also come across this issue since you’re using that program.
I have no problem using Puran Defrag (regular and boot-time defrag) with Avast. I also use CCleaner’s registry cleaner without problems with Avast as well.
What is the deeper sense in defragging the registry?
Even cleaning it is not really needed, but defragging?
Shrug. So that it is not scattered all over your drive? Mostly snake oil, unless you have a huuuuge registry and really slow HDD, at which point I am afraid you have much bigger problems than fragmented registry files. 
…unless you have a gigantic, super extremely huuuuge registry and really unbelievably slow HDD…
;D
Defragmentation: does not harm, on contrary.
Cleaning, hmmm…, generally does more harm than any good. The myth of a faster computer is still on the air…
Puran Defrag is quite good.
This is about defrag of registry. That’s just simply unneccessary. 8)
Defragmentation of disk is okay - unless you run Vista or higher. There is no need any more because Vista and 7 defrag “on the fly”.
Well most people say its snake oil but I have noticed improvements after use from prior to use getting frequent crashes and blue screens from corrupted registry conflicting I usually do not notice speed issues such are usually the result of hard drive fragmentation!
Well, registry cleaning - okay, maybe now and then it may straighten issues out. Rare, but possible.
But registry defragmentation is just a waste of time and hazardous since it can destroy the reg-file when you’re unlucky. 8)
Sorry, but why do you think you may cause any harm on defragmenting the files? ???
Just like any operation where parts of a file are read, rearranged and written back.
Every normal HD-defrag tool shows some kind of “warning” like “information may be lost”, and the registry is nothing but a file.
Any decent file defragmentation tool has security routines to avoid file degradation.
The computer could fail, the power could be turned of… They’re prepared to not degrade the files.
I admire your strong believes in technical achievements (after all you are called Tech ;D ).
Anyway, even if it is not hazardous, it is unneccessary.
Like any other file fragmented on Windows, it could be defragmented.
Even more if it is often used.
Win Vista and Win 7 defrag constantly, on the fly. :
Used files? Myth…
If you are using Linux or a SSD then the majority opinion is that you don’t need to defrag either the drive or the registry
http://www.sevenforums.com/performance-maintenance/8998-ssd-defrag-not-defrag.html
http://www.ghacks.net/2010/06/07/does-linux-need-to-be-defragd/