Ok, sorry I disappeared for a few days. I’ve been busy working on this problem.
So far I’ve done these things:
- Malwarebytes scan - found and quarantined trojan.DNSChanger and trojan.Agent
- Microsoft Updates - successfully installed all recent patches.
Installed and ran these online scanners:
- TrendMicro Housecall - found & deleted several instances of malware on first scan; clean on second scan
- BitDefender - found one Rootkit, two Trojans, and one Backdoor, all heueristically. I manually deleted all files in which these were found. I can give you full names of these items if necessary.
Installed and ran these spyware scanners:
- Ad Aware - quick scan - found & deleted 66 tracking cookies
- SpybotS&D - full scan - found 1 tracking cookie.
- SUPERAntiSpyware - found 32 registry threats, 463 file threats. Registry threats included entries for Rootkit.Agent/Gen-GXServ which blocked a number of antivirus progams. SAS deleted all these threats.
- HijackThis - downloaded from Spywarewarrior.com and ran it. Log attached.
Note that I downloaded all of the above programs onto a Mac and then copied them to a CD (Malwarebytes) or across the LAN (all the others) to get them to the infected PC. I did this just to make sure that they were not corrupted by something lurking on the infected PC.
I also closely examined the contents of my router (a Dynex DX-E402) and could find no signs that it had been infected. It still had the correct DNS addresses (for OpenDNS) and I couldn’t find anything else that had been changed. Also, all of the other computers on the LAN still have the correct OpenDNS addresses.
My intention is to dismantle this computer, assemble a new one with new hard drive, mobo and CPU, put the old C:/D: hard drive into a USB dock and copy the data off of it to the new hard drive. However, I want to be sure I clean the existing hard drives up as much as possible before I dismantle the computer so that later when I copy the data off the old D: partition I will be reasonably sure the data is clean.
Edit: Also, the last thing I do before I dismantle it will be to take the two trojans, DNSChanger and Agent, out of quarantine and put them into the Avast! chest and email them to you, so you can try to determine why Avast! didn’t catch them.
I’m installing a new mobo and CPU so I can also install a full security suite and at least one realtime antispyware scanner and still get reasonable performance. The existing hardware is 2 1/2 years old so it’s due for an upgrade anyway.
Any suggestions as to my strategy are welcome. Also, if anyone spots any threats in the HijackThis log, please let me know and I’ll have HijackThis clobber them.
Update: I did a little more digging and found that Trend Micro has a later version of HijackThis. They also recommend a number of forums to which I can upload my HijackThis log. So there’s no need for anyone here to look at my log unless you want to. 
Thank you! Thanks so much for all the suggestions so far. I’m very grateful to this forum and the moderators for your assistance.
Alison
Current system configuration:
Asus M2N32-SLI Deluxe
2 GB Corsair DDR2 800
MSI NX8800GT
SoundBlaster X-Fi Extreme Audio PCIe
640 GB HDD containing C: (Windows) and D: (data) partitions
250 GB HDD for backups
CF/SD/SM/MS card reader (connected to internal USB header)
DVD drive
DVD burner
I also use an external drive for additional backups. The above scans included the internal backup drive but not the external, which is not attached.
Current LAN configuration:
DSL modem
Dynex DX-E402 router
D-Link DGS-2208 8-port gigabit switch
Linksys WRT54G Wifi router
four desktop PC’s running XP Pro
one Mac Mini G4 running Tiger
two laptops running XP Pro (not always connected)
All of the PC’s and the Mac are hard-wired; the laptops usually use WiFi connections