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Please re-read my post. I said when running a scan that YOU initiate. Scheduled scans are not initiated by the user, but even still. you don’t think that it’s possible that using the computer during a scan has the potential to compromise it further? If you’re having to run a scan, then most likely, it’s because Avast’s real time protection missed the threat that you’re looking for, or you believe that this is the case.
You can technically run a disk defragmenter, and use that disk at the same time too, but that doesn’t guarantee that there won’t be damage to files that you’re using, if the defrag app is trying to defrag the same files.
Nothing is guaranteed, and that is the way of things. I speak from experience.