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After the reboot the GUID-named RunOnce entry is missing, as you’d expect. Thankfully, no changes are seen in the actual executables that make up the product.
There are a few differences in the files listed in the folder tree under AVAST Software, implying the GUID-named file DID run. A Stats.ini file is different, a whole bunch of files in a subfolder named 13122401 (a superset of the name of the RunOnce entry) have disappeared, and a new and relatively small .bin file has appeared.
This seems like good news. Though it’s just one data point, it implies that regardless of whether the scheduled emergency update runs, the product is keeping itself up to date on a healthy system without regular reboots.
-Noel