The ones you have for Skype are essentially duplicates as the exclusions aren’t case sensitive, SKYPE or Skype or skype should be the same.

The last three are the same (?) I’m hoping the /…/ that is in the path is because the full path doesn’t fit in the column width in the screen. The wildcard * at the end excludes files, sub-folders and their contents, so any one of the first two you entered should cover the last three.

Note:
I don’t know if you are counting the C:.…\AppData\Roaming[b]Microsoft[/b]\Skype\ in the list of files that should be excluded as that wouldn’t be excluded in any of the exclusions you set.

I can’t see why one of the first two Skype exclusions doesn’t stop it from being scanned.