Getting Error 42060 on explorer.exe

Cleaning a laptop for a relative and getting an error message.

Generally I would go ahead and delete, but this is a very important file as it’s a Windows file.

What do I do?

Probably should have included this but the virus is the Win32:Vitro.

Follow the directions here to clean Vitro: http://forum.avast.com/index.php?topic=46429.msg390041#msg390041