Google chrome not running in Sanbox

I installed Avast IS last night and everything was working just fine, i ran a boottime defrag last night when I went to bed and now Google Chrome wont run in Sandbox mode. Currently running Avast IS 7, WinPatrol Free, SAS, Malwarebytes. Is this a problem with the new update or are one of my programs conflicting?

Malwarebytes protection is turned on and Windows firewall is turned off*

Does it run fine if you run chrome outside the sandbox?

Both Avast and Google Chrome run fine when I have Sandbox option turned off for Google Chrome.

If I remember clearly, I believe you need to clear the contents in the sandbox and then run chrome in the sandbox again, unless ofcourse you have already done what I stated above, then im not to sure.

You were very right, deleted the contents and it works now. Thank you(: