Yes, click on the ‘Refresh Firefox’ button.
What I have been doing before to be able to work without interruption, is I go to the task manager and kill the "explorer.exe" process. Then it stops.
Let us eliminate the general possibilities first. Since you mentioned that killing "explorer.exe" process is stopping the pop-up, I would ask you to re-run FRST.exe and type [b]explorer.exe[/b] in the search box. Click on "Search Files" and attach the log when done.