help!!! my computer have a viruses but cannot be deleted

how to delete the viruses in my hadisk but the file cannot be deleted ???

that is:M5VBVM60.EXE
rund1132.exe
blank antiviri (aut0exec.bat)
shell32.com
empty.jpg
hole.zip
unoccupied.reg

Try this

Boot time Avast Antivirus Scanning
http://www.digitalred.com/avast-boot-time.php

MBAM http://filehippo.com/download_malwarebytes_anti_malware/
update and run quick scan, then click on “remove selected” to quarantine anything found and restart

come back and post scan log here if you need more advice