Help Removing Win32:Sirefef-PL, Logs attached

'Lo there. Avast started catching Win32:Sirefef-PL [Rtk] on my laptop last night and despite my best efforts I can’t get rid of it. Attached are the latest logs from Malwarebytes, OTL, and aswMBR. I appreciate any help you guys can give me on this.

Also, I started running my computer in Safe-Mode with Networking after the threat was detected. Is this necessary/relevant, or should I switch back to the normal running mode?