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Sorry but I’m not seeing a pattern at all, if you didn’t install the Comodo AV then there shouldn’t be any co-resident/conflict problems as it would be the defence+ element that is loading those signatures into memory.
Neither Comodo AV nor any other AV were ever installed on this installation; only Avast 6.x. Only Comodo firewall and Defense+ plus MBAM Pro installed with recommended exceptions applied. I did change my Defense+ configuration to Proactive about a week ago. I was definitely running Proactive for a least a week prior to this problem.
At this point, all I can say definitively is something with Avast’s virus definition update yesterday trashed my PC. I had no problems prior to yesterday. Additionally, after I had restored my system and Avast had auto downloaded all available updates, I was still getting messages from WIN 7 Security Center that my definitions were not up to date where in fact they were. Rebooting again fixed that … at least yeaterday it was fixed; I haven’t logged on that PC yet today.