I think IE updates affects MyIE2
Quoted from download.com :
MyIE2 is a multipage browser based on the Internet Explorer core (IE 5.x or 6.0 required). It can open multiple Web pages in just one window, and it only takes a few system resources when you’re surfing with the integrated user interface. It supports special plug-ins and IE extensions, and its features include autoscrolling, form autofilling, external tools, plug-in support, newsgroup browsing mode, mouse gestures, customizable skins, and an autohide panel. The latest release includes a media player sidebar, a new search bar, and several performance enhancements.