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How are you being told it is “coming in?” Are you doing an Avast scan? What type of scan are you doing?
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Do you have a file in the Avast Virus Chest?
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What version of Avast are you using? 6.0.1125?
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What is the exact file name and location of the file that is infected?
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When did the problem start?
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What were you doing when it started?
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How is your machine acting? What kinds of problems are you having?