A Yes/No answer doesn’t cut it.

  1. If your computer is infected, it could infect mass mailings from your computer.

  2. It depends on the content of the popup script, a popup in itsself is not a virus, it is the malicious script content.

  3. Similar answer to 1 above, if the autoresponder is on your computer or the host is compromised (reputable company should take precautions to combat the spread of viruses), it could spread a virus, but more likely not.

  4. Much the same as 2 above.