Why …

First of all, all content stays in the Sandbox untill you delete it.
So the Sandbox will occupy more and more disk space in time.
I don’t know if there is a size limit, except of course the maximum free disk space available.

What could have happened is that, after an update of Chrome, new files were coppied into the Sandbox and old files not longer needed were not deleted.
And that caused some kind of conflict. But it is only speculation.

I would regularly delete the Sandbox contents.
And as you maybe have seen, you can scedule that if you want.
Personally I manually delete the Sandbox contents every week before I make a system image.
But sometimes I do it even twice a week.

About the reboot : When the Sandbox is still in use ( for example by a system file ) you can’t delete the contents. A reboot solves that.

Greetz, Red.