The version 4.5 has a new mail detection that will work automatically. Please, set up your email account just as avast does not exists. It will detect the pop3/smpt/imap ports and scan your messages. Can you make a try and see if it’s ok? Thanks.

New email detection is automatic and do not require user interaction. Anyway, spam killer applications need manually change email account settings :wink:

This is by design.
In 4.1, it was like: mail client > avast > spam killer > mail server
In 4.5, it’s like: mail client > spam killer > avast > mail server