I just wanted to ring in on this issue. I just had an elderly customer come in - he has everything on his computer set to large as well. Installed Avast and could not see or access proper buttons to work with Avast - I had to temporarily change customers resolution to complete the installation. Then decided it’ll never work properly on his computer and removed Avast - I installed another AV which was better suited for his display settings.

It’s too bad there isn’t a resizable option like Dave mentioned. Hopefully there will be a solution - my elderly customers often have their displays set to large print/icons and this will be a problem.