If a virus is replicant (coming and coming again), you should:
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Clean your temporary files. You can use CleanUp or the Windows Advanced Care features for that.
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Schedule a boot time scanning with avast. Start avast! > Right click the skin > Schedule a boot-time scanning. Select for scanning archives. Boot. Other option is scanning in SafeMode (repeatedly press F8 while booting).
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It will be good if you download, install, update and run AVG Antispyware. Some users recommend SUPERantispyware, Spyware Terminator and/or a-squared (take care about false positives).
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Use the immunization of SpywareBlaster or, which is better, the Windows Advanced Care features of spyware/adware cleaning and removal.
Note: System Restore is not available in Windows 2k.