Please Help with Malware or virus http://wpad.net/wpad.dat

Hello,

Can anybody help me to remove this malware or virus.
The computer is contacting http://wpad.net/wpad.dat even when I am not using the internet.
Is it very dangerous?

Thanks Edgar

URL: http://wpad.net/wpad.dat
proces: C:\Windows\System32\dllhost.exe
infectie: URL:Mal

URL: http://wpad.net/wpad.dat
proces: C:\Program Files (x86)\Microsoft Office.…
infectie: URL:Mal

Please follow these instructions: http://forum.avast.com/index.php?topic=53253.0