Even so, your business you work/own for. Should have firewalls on it. The computers should be mostly protected…

I’d still say.

Avast QuickScan = Monthly
Malwarebytes = Weekly to Bi-Weekly
CCleaner = Monthly.

Honestly, CCLeaner just clears Temp files, browsing history. Which most of that is cleared when you restart. But even so, scanning that much isn’t needed.