Lets put it this way, are you prepared for any such PUP detection.
Do you know what is installed on your system and what it does and if that may be considered a PUP.
PUP = Potentially Unwanted Program - See http://searchsecurity.techtarget.com/sDefinition/0,,sid14_gci1066761,00.html. Not included in this definition are tools which can be used for good or evil, some have been legitimately installed for a specifically good purpose, but could have been unknowing installed for a malicious purpose.
Not all antivirus programs scan for PUPs and avast has it turned off by default (an exception being the boot-time scan).