system
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Comodo provide a real-time AV for Linux - but they only claim that it is looking for windows platform malware. I guess it would pick up some cross-platform malware as well. I’ve given it a try (on Ubuntu 12.04), and it seems to run OK but it’s not installed any more.
I now tend to the same view as FreewheelinFrank (and may well have learned it from him amongst others).
I don’t install from outside the repositories, and have a separate account for sensitive web transactions - and use it only for that. The browser in that account only visits a few trusted websites and is free of all add-ons but Noscript. I also run Apparmor profiles in enforce mode on all outward facing Apps.
I’ve not had a malware problem. Then again, I never did with Windows!