Registry Problem?

Request help with a problem I can not solve.
I have installed Windows 7 Ult., Avast premier and Adobe Digital Edition 2.0, and eReader Tagus Lux.
Everything was fine until I decided to replace the ADE ADE 1.7 2.0 (did well data migration and authorization in force) and access the book house through iTunes.
From that moment the .acsm can not join the ADE. Not even listed ADE program and can not be selected.
I’ve tried Avast, MWB, OTL, ADW and some registry cleaner but nothing. Att. reportADW.
I think the only solution is to “touch” the registry but I have not dared.

You can Help?

Hi, post the OTL and MBAM logs. Then someone can check

Hey Alan, thanks for your help.
Unfortunately my attempts to alter the registry produced irreparable damage. (Beware Types program).
Format and start over.
Thanks anyway.

Rafa