Going on nothing other than its location, a .sys file in a temp folder is highly suspect.
Google searches also tend to support this detection, http://www.prevx.com/filenames/347393630340283230-X1/PNICML.SYS.html. You have to take care when googling such suspect file names as there are sites out there which purport to help clean them and they in themselves are bad.
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You could also check the offending/suspect file at: VirusTotal - Multi engine on-line virus scanner and report the findings here, post the URL in the Address bar of the VT results page. You can’t do this with the file securely in the chest, you need to extract it to a temporary (not original) location first, see below.
Create a folder called Suspect in the [b]C:[/b] drive. Now exclude that folder in the File System Shield, Expert Settings, Exclusions, Add, type (or copy and paste) C:\Suspect*
That will stop the File System Shield scanning any file you put in that folder.