Scanning in Safe Mode

Hello all thanks for answering my first time post,my ? now is is it better to do a boot time scan at start up than a regular thourough scan.I heard maybe it is true or not u get better scans in safe mode is that true and why.?

The boot time scanning is as deep as the thorough into Windows.
I think you do not have to run it more than once each two months, for instance, if you have avast resident turned on all the time.