Threat: Rootkit: system modification

When running my avast antivirus on a thorough scan, it finds several High Severity threats identified as “Threat: Rootkit: system modification”. It always recommends I repair the file, and the result says “Action postponed until the next reboot.” At which time is always prompts me to run a boot-time scan which I do. During the boot-time scan, these threats are not found. However, upon re-running my thorough scan, it finds that these same threats remain. I am at a loss as to how to remove these threats. I’ve noticed my computer running slowly lately, so I know that these threats are real. I just wish I knew how to get rid of them. Why is it that the boot-time scan does not find these threats and the thorough scan finds it every time? I’ve got the boot-time scan set to the highest sensitivity. I’d appreciate any advice. Also, it appears that most of these threats are all located in “C:\Windows\winsxs\” directory. I am running Windows 7 and I am using the free version of Avast. Help!
Please and thank you.

Looks alot like my problem (rootkit) I am running windows XP.
Hope you get it fixed soon. There are good suggestions in here.

UPDATE:
I ran Malwarebyte’s Anti-Malware Program on my computer. It found several infect registry keys which it successfully quarantined and deleted. I then ran Avast and targeted the specific file folder which most of my infections were located and it came up with no infections. I will be running my normal scan and scan the entire computer to see if all situations have been fixed. But at this point, it looks very hopeful. I may consider purchasing the Malwarebyte’s program and run it along with Avast, unless anyone has any better suggestions.