I mentioned before that the number of false positives reported by Avast seems to be increasing dramatically.
An article was just published which discusses this issue for the entire industry: http://betanews.com/2015/05/18/traditional-security-approaches-produce-too-many-false-positives/
Each time users encounter a virus warning from Avast, it stops their workflow and forces them to spend their time determining if the warning is due to malware or another false positive. It can often take 4+ hours of work to accurately make that determination (sometimes much longer).
Avast has three ways to submit files so they can analyze them, although the two most prominent ways (through the Avast Antivirus interface and through the online Avast Labs) both fail when trying to submit large files. When the submission is successful, Avast seems to be very good about evaluating the submitted files. Users should be aware that it can take many days for Avast to evaluate any files; this can leave a user in limbo for quite a while.