UI Failed to Load? AV service is not responding

Avast Cleanup
1

I have no clue why this has happened.
Purchased clean-up license until Apr 2018.

Anybody help!!!

2

More details might help.

Did you run CleanUp?

3

See picture—

http://s6.postimg.org/nsjmmaz4h/screenshot_400.jpg

4

What OS/SP ?