Uninstall Browser Plugins?

Since I have decided to forget the Sandbox in Pro 7, is there any advantage/disadvantage to uninstalling the browser plugins?
I am going to try to run Trusteer and forget the Sandbox. Trusteer conflicted with the Sandbox, but seems to run OK if I do not use the Sandbox. I have not seen any conflict with SafeMode. It is not difficult to browse with the SafeMode, but a little easier with Trusteer or sandboxed if it would work.

Thanks,
Jerry