Because of a problem with my hands I prefer to use a Wacom tablet instead of a mouse. Trouble is, my tablet is not active when I use Safe Zone. I tried searching these forums and could not find a solution. Any suggestions on making my tablet work in Safe Zone would be appreciated.
Hi hew39, welcome to the forum 
I am not familiar with the Wacom tablet.
But what you can try is to add the Wacom executable ( Tablet.exe in the C:\Windows\System32 folder ? ) to SafeZone.
You can do that with the (+) icon in SafeZone.
Greetz, Red.