Hi ltunstall 
The SafeZone issue can be solved like this :
- Start - Control Panel - Add/Remove Programs - Avast! - Change.
- Change.
- Uncheck SafeZone.
- Continue.
- Reboot.
Now follow the same procedure, but in step 3 you check SafeZone to install it again.
( For the malware related issues follow the instructions Asyn has posted above )
Greetz, Red.