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The profile on my computer was no roaming profile. It was just the user account of my wife on my home computer. I didn’t use Avastclear. I just uninstalled Avast and the problem disappeared, reinstalling Avast reintroduced the (mis)behavior several times. I saw no other possibility as to install another antivirus program.

Was there any chance that the use of Avastclear (after uninstalling and before reinstallation of Avast) prevented the misbehavior?

It’s a strange problem. There is nothing special on the account of my wife. It’s a local Windows10 (user)account without administrator rights. the only special thing is her very unsafe password. I did not install any programs in the last days that could cause the problem (I did not check which other programs could be evildoer in cooperation with Avast). I suppose Avast is not the only wrongdoer, otherwise the problem will arise on every Windows 10 computer.