Microsoft used to have a dedicated PDF file reader. You now read text on Edge. I think Chrome stopped audio at some point adding it as an add-in w/ a security breach warning. I also noted on my older computer these readers often ran slow/froze up.
I now use a free download that I copy browser text (or other) into. It is secure but lacks Find for looking up text, if you want to skip. Many pages (pdf especially) on the Web only let me copy all or nothing. Perhaps a button that when clicked directs you to an app on your start page, manually brought up w/ a Find, and things like delete partial text to skip over, maybe a larger cache of stored data so that files don’t need to be split up, and the ability to bookmark upon shutting down w/o saving a file to audio, that allows the listener to start where he left off earlier.
If you follow along on your browser to see photos, charts, and carefully review a paragraph, while otherwise sitting down, lying in bed, just popping up when needed to read the browser, I find this helpful for eyestrain. The text reader strips photos, possible links, just leaving plain text.