Avast caught a VBS:Bicololo-BR trojan - all clear, or does a threat remain?

Viruses and worms
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Hi forums! First time posting to learn more about how computer viruses work and find out some opinions on the Trojan my Avast picked up yesterday. I am no computer expert, so I don’t know if I should be worried or if everything is under control/the alert was a false positive.

After closing a private browsing window and relaunching Opera, Avast caught a threat in my History Provider Cache, named VBS:Bicololo-BR[Trj]. From what I’ve googled, this could either be a serious Trojan redirecting me to scamsites, or a false positive since it seems some people have experienced similar alerts when opening up Chrome.

The infected file was moved to chest, subsequent full scans and boot scans showed nothing. Installed Malwarebytes, which caught a fair amount of older malware that Avast has missed, but as they are older files I don’t think they are related to this incident. So far, so good?

But I guess this is my problem, since I know so little about viruses: why would it be detected as I launched my browser? And how does a History Provider Cache become infected? Trojans AFAIK usually come from suspicious links or downloaded files, which I to my knowledge have not clicked in recent times. Is there a chance that a trojan still remains deeper in, and Avast only caught a small part of a process? How can I be certain that I do not have a severe security threat lurking on my hard drive?

Sadly, I don’t recall the exact infected file directory. The quarantined file does not show up in chest, which I assume is because CCleaner autocleanses the browser cache every so often, which has resulted in deletion of the file.

I would greatly appreciate any advice or thoughts on this matter. Thanks!

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But I guess this is my problem, since I know so little about viruses:
In your case not a virus but a trojan

VBS:Bicololo-BR[Trj] = Trojan
VBS = Visual Basic Scripting

5 February 2013 - Bicololo https://blog.avast.com/2013/02/05/bicololo-virus-spreading-via-webserver-errors/

How can I be certain that I do not have a severe security threat lurking on my hard drive?
Nothing is 100%
Avast caught a threat in my History Provider Cache
Clear your browser cache

You may also run Malwarebytes Adwcleaner (not the same as Malwarebytes Antimalware)

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Thank you for the tips!

I ran Adwcleaner and it caught a handful of stuff, but they also seem to at least stem from some older files. Good to have them cleared out, but I also doubt they are related to the trojan at hand (which I learned is not the same as a virus, so thank you for that as well!). I also went ahead and purged most caches and other temporary files from both browsers and other programs using CCleaner.

I understand that you can only be completely certain if you just buy a new computer, but there must be something I can do to at least increase the chance of my computer being safe to use. I would very much not like to get phished by an unnoticed redirect.